Alan Henry at Lifehacker has a great breakdown of how to make your workplace better from any level -- entry, middle management, and executive. For now, though, let's just look at his recommendations for the little guy.
1. Make yourself happier. If you're constantly gossiping around the water cooler, never taking any vacations, or just plain don't have the coping skills to deal with stress well, you might want to check out this list of ways to love the job you're with.
2. Talk to your manager. If it's definitely them, not you, the first step is to talk to your boss. Offer a solution (a team potluck, a company outing), not another problem (more whining with no suggestions as to how to fix things).
3. Connect with your colleagues. Find ways to break down the social barriers between you and your work neighbors. Henry suggests a chili cook-off, which is awesome because a) friendly competition is a great way to get people chatting, and b) chili.
4. Organize. Before you go all Norma Rae, make sure your colleagues are on board, and stick to small suggestions first -- the aforementioned chili cook-off, a quiet space to work or eat lunch, etc.
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